A 2006 review summarised the state of the field bluntly, describing the molecule as an unresolved riddle decades after its discovery (PMID 16539679)
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Arch Gerontol Geriatr 46:181190 Malaguarnera M, Vacante M, Bertino G, Neri S, Malaguarnera M, Gargante MP, Motta M, Lupo L, Chisari G, Bruno CM, Pennisi G, Bella R (2011) The supplementation of acetyl-l-carnitine decreases fatigue and increases quality of life in patients with hepatitis c treated with pegylated interferon-alpha 2B plus ribavirin