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The peptide is created by the inclusion of 13 amino acids to the N-terminus of native IGF-1 and by replacing the glutamic acid at position 3 with arginine, which ultimately leads to the formation of an 83 amino acid peptide

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GZFLW was observed to increase the ratio of Bax to BCL-2 in a dose-dependent manner and at the same time up-regulating the tumor suppressor gene p53 (Lee et al., 2019)

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