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Discussion This review evaluates the effect on HR of six approved GLP-1 RAs, categorized into a short-acting sub-class with half-lives of 35 h (exenatide BID and lixisenatide) and a long-acting sub-class with half-lives ranging from 12 h to several days (liraglutide, exenatide LAR, albiglutide and dulaglutide) [16]
SGLT2 inhibitors, such as empagliflozin and canagliflozin, have similar A1C-lowering properties (0.5%-0.8%) and out-of-pocket costs (except for alogliptin, which is available generically), but have the added advantages of CV risk reduction, BP-lowering, and weight loss
Am J Clin Dermatol 9:1531 Donath MY, Shoelson SE (2011) Type 2 diabetes as an inflammatory disease
