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In this sense, in rat models of lung cancer (squamous cell carcinoma of the lung), high plasma levels of cadaverine were associated with disease progression [244], a finding that might indicate its roles not only as a biomarker but also as a causative agent for this specific tumor

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Ex vivo studies using aged kidney slices show FOXO4-DRI induces apoptosis in senescent cells within 3 days, demonstrating direct renal tissue penetration and efficacy

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