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The underlying mechanism is TD-induced impairment of PDHC activity, which causes remodeling of glucose metabolism in the macrophages
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Hepatic Fat Reduction Data In the retatrutide phase 2 trial, MRI-PDFF-measured hepatic fat fraction fell from a mean of 15.2% at baseline to 3.0% at 48 weeks in the 12 mg group, a relative reduction of 81.1%
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