FDA-approved GLP-1 medications are generally considered safe for most people, but there are quite a few people who should avoid them altogether, including those who have: Family history of thyroid cancer Family history of pancreatitis Gastrointestinal conditions Pregnancy or breastfeeding Diabetic retinopathy History of eating disorders Each of these GLP-1 medications provides important safety information on its website, including possible side effects from taking the drug
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Problems in GLP-1RA development Cost-effective and reliable trial endpoints for MASLD medication Assessing long-term liver benefits in clinical trials has remained a complex issue
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Thus, the cerebro-protective effects of DPP-4 inhibition may be another consideration for treatment of T2DM patients at risk for development of cerebrovascular disease or cognopathy