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Avoid in severe kidney impairment or dialysis

Some patients find that evening dosing helps them manage daytime nausea, whilst others find morning administration allows them to eat lighter evening meals, which may further support weight management goals

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These localized reactions often stem from the injection technique, needle sensitivity, or mild inflammatory response at the injection site and do not necessarily indicate an allergy to the medication itself

The heavier people are, the more likely it is that they have a dysfunction, he says

Plan your dose increase for a day when you can rest if needed