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4.6

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Description

Previous studies have shown that infusion of recombinant human IGF-1 to the sheep fetus for 3 hours yielded small (6%) but statistically significant increases in fetal plasma concentrations of IGFBP-1, IGFBP-2, and IGFBP-3 despite large (74%) increases in IGF-1 concentrations ( IGFBP-1 also increased with infusion of recombinant human IGF-1 in the setting of normal fetal insulin and nutrient concentrations, but expression of IGFBP-3 did not change ( IGFBPs 13 in the liver and skeletal muscle

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