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This genetic defect can also cause aortic root aneurysms, and aneurysms in the circle of Willis cerebral arteries, which, if they rupture, can cause a subarachnoid hemorrhage

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doi: 10.1038/s41366-018-0302-z 120 MaritzGMutemwaM

These molecules form a coordinated network that enhances oxygen unloading from hemoglobin

Furthermore, the link between astrocytic metabolism and neurodegeneration is gaining traction: during brain aging or degenerative processes, the efficiency of astrocyte-neuron metabolic couplingcritical for glutamate homeostasis via transporters like GLT-1 and GLASTdeclines, leading to reduced glutamate clearance, extracellular accumulation, and NMDA receptor-mediated excitotoxicity, which drives neuronal dysfunction

Sustainable weight loss results require adjustments to lifestyle, activity, and diet