CINeMA assesses six domains: within-study bias (informed by the Cochrane RoB 2 tool) ( The outcomes of interest were metabolic parameters reflecting the efficacy of each intervention in improving metabolic profiles among women with polycystic ovary syndrome
The retatrutide dose schedule follows a similar escalation pattern, suggesting it will likely require long-term use for sustained benefit
Rights and permissions About this article Cite this article Mahapatra, M.K., Karuppasamy, M
doi:10.1073/pnas.1525639113
if GI adverse events appear during the dose-escalating phase, HCPs could modify the planned schedule by implementing one or several of the following points: extend the dose-escalation phase duration (24 more weeks with the previous dose or temporary suspension) avoid dose escalation while GI adverse events persist if a GI adverse event is experienced when moving up to a higher dose, go back on the lower one and stay on it for a few days
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