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Some preclinical work explores FOXO4-p53-targeting peptides against senescent cancer cells, and the developer has discussed cancer as a research interest, but there is no human evidence that FOXO4-DRI treats cancer

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At the same time, we also have to acknowledge that many of these compounds still lack large-scale human clinical trials and long-term safety data

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Over time, it can cause irreversible nerve damage, cognitive decline, and mental health disorders such as depression