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Given the modest treatment persistence observed in clinical practice,our results may not capture long-term cardiovascular outcomes

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Brown Norway rats that did not undergo any treatment (PQ or eye drops) were also included as a healthy untreated control group

At 48 weeks, participants in the 12 mg group achieved a mean weight reduction of 24.2% compared to 2.1% for placebo

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Individuals with severe gastrointestinal disorders, such as gastroparesis