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Daniel Drucker [Biomarker 2023] GLP-1 agonists carry a black box warning for C-cell medullary thyroid cancer, an event that was noted in animal studies, but never in human patients in decades of clinical trials
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These agents regulate glucose metabolism by enhancing insulin secretion, suppressing glucagon release, delaying gastric emptying, promoting weight loss, and improving cardiovascular health (Bendotti et al., 2022)
The FDA has approved semaglutide for two distinct indications: treating patients with type 2 diabetes (under the brand name Ozempic ) and chronic weight management (under the brand name Wegovy )
Large cardiovascular outcome trials show reduced cardiovascular events despite small heart rate increases
You come out leaner and stronger, not smaller and softer
