The peptide upregulates MMP-2 expression in dermal fibroblasts by 85%, facilitating breakdown of damaged collagen and enabling cellular migration through dense matrix environments, while simultaneously enhancing production of tissue inhibitors of metalloproteinases (TIMPs) to prevent excessive degradation
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Possible side effects are not well defined because no controlled human safety trial exists
Ronan JL, Wu W, Crabtree GR
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Future research should focus on large-scale, well-controlled randomized trials with standardized dosing protocols, clearly defined deficiency thresholds, and long-term follow-up to strengthen the evidence base and guide clinical practice