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Paricasitol as a VDR agonist can inhibit ferroptosis by activating VDR/Nrf2/HO1 signaling pathway in DN, which effectively attenuates iron deposition in renal tubular epithelial cells and renal damage after diabetic injury [82]
& Zhang, Z
They created an acute skin inflammation model in 23 healthy volunteers and measured the accumulation of inflammatory cells and factors within the inflamed skin
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Furthermore, acute oxidative stress induced by acetaminophen markedly upregulates expression of FGF21, -Klotho and antioxidant enzymes in hepatocytes (150)
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