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Safety Profile and Potential Side Effects Reported Adverse Effects Animal studies report minimal toxicity even at high doses

[51] Diagnosis [edit] According to one review: "At present, no 'gold standard' test exists for the diagnosis of vitamin B 12 deficiency and as a consequence the diagnosis requires consideration of both the clinical state of the patient and the results of investigations." [52] The vitamin deficiency is typically suspected when a routine complete blood count shows anemia with an elevated mean corpuscular volume (MCV)

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Recent gene profiling studies allow deeper understanding of mechanisms of its positive actions

Gamma-aminobutyric acid-glutamate interaction in the control of somatostatin release from hypothalamic neurons in primary culture: In vivo corroboration