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Moreover, research has emphasized that apoptosis, lysosomal dysfunction, and altered autophagy are associated with salivary gland insufficiency and autoimmunity in SS [278,279,280]

Silencing SIRT1 gene or inhibiting it pharmacologically with Ex-527 can reduce cell ferroptosis and inhibit EMT, 90 suggesting that epigenetic reprogramming of EMT helps to promote ferroptosis in HNC cells

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However, because of potential side effects like skin rashes or the reversion effect where results fade after stopping treatment, you must not attempt to self-medicate