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H 2 O 2 has a longer half-life and can cross membranes (Sies, 2014), which confers properties to H 2 O 2 as a mitochondrial signal (Raimundo, 2014)

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Seiler A, Schneider M, Frster H, Roth S, Wirth EK, Culmsee C et al (2008) Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent-and AIF-mediated cell death

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