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It has been shown to exert beneficial effects both alone and as an adjunct to standard medical treatment (Allen 2013

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2009 in British Journal of Dermatology : a double-blind randomized controlled trial of a cosmetic anti-ageing product in photoaged skin, which showed measurable improvements in fine wrinkles, mottled pigmentation, and roughness 10

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Furthermore, the expansion of the liquid can compromise the mechanical integrity of the pens glass cartridge