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The parent compound is proposed to interact with gene regulatory regions, including the hTERT (telomerase reverse transcriptase) promoter, modulating telomerase expression in somatic cells
Kamenov, Z
Carr M, Fandre MN, Oduwa FO
This was Citius second try for FDA approval, after the regulator rejected Lymphir in July 2023, outlining the need for enhanced product resting requirements. In its resubmitted data package, the company included findings from the from the Phase III Study 302 trial, where treatment with the drug led to an objective response rate of 36.2%, with 8.7% reaching complete response
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Ideally, it should be maintained at approximately 40 minutes, as this constitutes the minimum requirement for ensuring the regeneration reaction proceeds to completion
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