Persistent vomiting, severe nausea that prevents eating, diarrhea lasting more than a week, or any symptom that significantly impacts your daily functioning requires medical attention and likely a dose adjustment
2018;19:e46666
Contraindications Pregnancy and lactation: individual case reports suggest safety during pregnancy (de Bruyn 2015), however data which mainly include in vivo studies (Xi 2008) are insufficient
The FDA still has to decide what happens next
Surveillance of chronic disease risk factors: Country-level data and comparable estimates
Ellenbroek JH, Tons HA, Westerouen van Meeteren MJ, de Graaf N, Hanegraaf MA, Rabelink TJ, Carlotti F, and de Koning EJ