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Safety concerns arise with overthecounter peptide purchases: lack of FDA approval, purity, and potential immunogenicity

A striking illustration of gutbrain neural connectivity is seen in PD: misfolded -synuclein protein aggregates, a hallmark of PD, are hypothesized to originate in the gut and spread to the brain via vagal nerve fibers in a prion-like fashion [31]

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Blood work (if accessible): Pre-cycle and mid-cycle blood panels can reveal changes in IGF-1 levels, fasting glucose, and prolactin

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Using alcohol swabs on vial tops, never touching needle tips, and avoiding multi-use of single-use components maintains safety