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That year Charles Kimball, a biochemist, and John Murlin, a physiologist, at the University of Rochester in New York, isolated a substance in the duodenal and pancreatic mucosa of dogs that raised blood sugar levels in depancreatised dogs

Integrating UPR-targeted therapies with autophagy-mitophagy or chaperone-based strategies may yield synergistic neuroprotective effects

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These changes reduce binding to IGF binding proteins (IGFBPs) by approximately 100-fold while preserving full affinity for the IGF-1 receptor (IGF-1R)

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