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Tirzepatide targets both GLP-1 and GIP receptors (dual action)
The balance between such effects, particularly over a prolonged timeframe, including effects at other GHSR1a monomers or GHSR1a heterodimers with other receptor types, must be taken into consideration
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GLP-1RAs alleviate liver injury by inhibiting hepatocyte apoptosis and promoting the TFEB-dependent transcription of lysosome-related genes, which stimulates hepatocyte autophagy to prevent lipid accumulation (Elsiad et al., 2025
doi:10.1056/NEJMoa2307563 60
However, our study has several limitations
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