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Some of the DPP-4 inhibitors are substrates of DPP-4 whereas others bind to the catalytic site without being degraded

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Research uses MT-1 to establish the reference pharmacodynamic profile for MC1R activation , characterising concentration-response relationships, receptor internalisation kinetics, and downstream melanin synthesis biology that serve as the benchmark for evaluating other melanocortin agonists and antagonists at MC1R

The dataset will be available to pharmaceutical researchers for advancing therapeutic development