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For M2 macrophages, some subtypes of M2 macrophages (M2a, M2c) produce anti-inflammatory factors such as IL10 and TGF, while some subtype (M2b) secrete TNF, IL1, IL6 and IL10 ( Innate immune responses are characterized by the initial influx of polymorphonuclear leukocytes, followed by monocyte-derived macrophages, ultimately leading to tissue resolution and the restoration of normal physiology ( 4.2.2 Lipid peroxidation and DCs As professional antigen-presenting cells, DCs were reported to exhibit increased lipid accumulation in tumor-bearing mice and cancer patients ( + T cells ( Lipid peroxidation is a double-edged sword for the function of DCs

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They react with DNA, they react with proteins, they react with lipids