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People with mild B12 deficiencies experience changes in B12 effectiveness yet severe deficiencies need extended treatment time or stronger doses to produce noticeable results

Saibal K Biswas, Danny McClure, Luis A Jimenez, Ian L Megson, Irfan Rahman - Curcumin induces glutathione biosynthesis and inhibits NF-kappaB activation and interleukin-8 release in alveolar epithelial cells: mechanism of free radical scavenging activity - Antioxid Redox Signal - Jan-Feb 2005

Was it left out for two hours or eight

BINET L et al

When is the best time to take it

I always tell my patients to set phone alarms or keep a simple notepad handy