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doi: 10.1084/jem.20110698 21 WongAWXiaoJKemperDKilpatrickTJMurraySS
Hand JR: Interstitial cystitis
The maximum dose permitted by health authorities is 3000 mg
Large-scale, well-designed trials with proper randomization and blinding are needed to determine whether high-dose oral supplementation is as effective as intramuscular injection for increasing vitamin B 12 status and alleviating clinical symptoms of vitamin B 12 deficiency
However, in a subanalysis of participants with low vitamin B 12 status at baseline (n= 101), the B-vitamin supplementation slowed the decline in bone mineral density (total hip and femoral neck but not lumbar spine) (116)
It is a tripeptide made of three amino acids produced in the liver
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