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For vascular disease, management includes risk-factor control, supervised exercise therapy, medications to improve walking distance or prevent clotting, and sometimes angioplasty or bypass surgery

Rare adverse effects that may indirectly affect the kidneys include pancreatitis (which can cause systemic inflammation and prerenal AKI) and allergic reactions

Dr Steward said the rise in off-label prescribing is concerning but the results here should still be enough to ring alarm bells

Still, the mechanism involved remains unexplained and surprising given that they also increase heart rate and acutely increase cardiac output

Waiting two or more years for an unapproved drug class is rarely the best option for someone who is losing weight and has medical reasons to stay on treatment

Your first 4-6 weeks of treatment will be closely monitored to ensure safety and effectiveness