Table S9
The inner two-thirds does not
When you swallow the capsule, the peptide is delivered directly to the site of the injury (the stomach and intestinal lining)
High glucose increases glomerular filtration barrier permeability by activating protein kinase G type I subunits in a Nox4-dependent manner
But access to the drugs has been a consistent problem for patients because of their cost around $500 a month for higher doses and insurance coverage has been spotty
Baric I, Zschocke J, Christensen E, Duran M, Goodman SI, Leonard JV, Muller E, Morton DH, Superti-Furga A, Hoffmann GF: Diagnosis and management of glutaric aciduria type I