Signal Transduction and Targeted Therapy, 2 (1), 1-9
Masaldan, S
K63-linked ubiquitination, which typically regulates signaling, DNA repair, and autophagy rather than degradation, is frequently altered in PD, AD, and ALS
demonstrated that 8-oxoG in the telomeric region has a dual role, either hindering telomerase-mediated elongation when incorporated as 8-oxodGTP or promoting telomerase activity by destabilizing G-quadruplex structures when preexisting in telomere DNA
These patients represent a very small proportion of the population (approximately 1 of 200,000 individuals in the world) and have very severe hyperhomocysteinemia that can reach 400 mol/L
Although our in vivo data robustly demonstrate multi-system recovery, the intricate cellular and molecular crosstalk underlying these effects invites further elucidation through reductionist in vitro models