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Results showed that a small alteration in the GLP1R gene plays a role in how well the drugs will work in individuals

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Mounjaro was originally FDA-approved for type 2 diabetes and is commonly prescribed off-label for weight loss under medical supervision

exenatide once weekly, dulaglutide, albiglutide, liraglutide [12]

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However, it should also be recognized that it may be difficult to definitively demonstrate whether DPP-4 does play a physiologically relevant role in cleaving some endogenous substrates in vivo because it can be difficult to distinguish between the intact substrate and the truncated metabolite (because assays are not specific or sensitive enough) and/or because it may be difficult to obtain appropriate samples (e.g., from synapses [neurotransmitters] or interstitial fluid [paracrine signallers])