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The physiological basis of our model is the reaction diagram [Figure 1] and the K m values for the enzymes
In 1999, James and coworkers reported increased plasma hcy levels and an increased frequency of both MTHFR 677CT and TT genotypes in mothers of DS individuals (MDS) with respect to control mothers, and that paper opened the way to the study of folate gene polymorphisms as maternal risk factors for the birth of a child with DS (James et al., 1999)
Weinstock LB, Walters AS
Curr Opin Hematol (2016) 23(3):2539
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