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In clinical use monitored by post-marketing surveillance and in the long-term cardiovascular safety studies, no serious imbalances in safety signals were observed (12, 19, 21, 22, 2433)
In many cases, it is an energy availability issue
For example, hypertension and insulin resistance have been shown to significantly impact sleep for the worse
Lipotoxicity in cumulus-oocyte complexes reduces fertilization rates, showing diet and body fat act together to harm egg health
Frias JP, Nauck MA, Van J, Kutner ME, Cui X, Benson C, et al
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