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These medicationsincluding semaglutide (Ozempic, Wegovy), dulaglutide (Trulicity), and liraglutide (Victoza, Saxenda)use very fine needles (2932 gauge) designed to reduce pain during subcutaneous administration
The DPP-4 inhibitor CV safety outcome trials have unequivocally demonstrated that DPP-4 inhibition is not associated with any increased risk of major adverse CV events (MACE), with the four trials so far published (124127) having hazard ratios (HR) for the primary outcome of between 0.96 and 1.02 (Table 2)
Injecting the medication should proceed slowly and steadily
10.1038/nrneurol.2010.127 Nat
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