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Additional pathways implicated in tubulointerstitial injury and renal fibrosis include TNF- and tissue inhibitor of metalloproteinase mRNA-1, which facilitate fibrosis by preventing the breakdown of collagen (93)

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Its plasma concentration decreases with age: approximately 200 ng/ml at age 20 versus 80 ng/ml at age 60, correlating with the decline in regenerative capacity

H.KumarP.KohliK.NajmiA.et al (2021)