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Genetic polymorphisms of human N-acetyltransferase, cytochrome P450, glutathione-S-transferase, and epoxide hydrolase enzymes: relevance to xenobiotic metabolism and toxicity
doi: 10.1038/nature12940 501 PantazisNPapastamopoulosVPaparizosVMetallidisSAdamisGAntoniadouAet al
doi: 10.1080/00207454.2021.1885403 189 MitraSChakrabartiNBhattacharyyaA
This suppression subsequently promotes excessive hepatic bile acid synthesis, resulting in inflammation and liver injury
Ogitani, Y., Hagihara, K., Oitate, M., Naito, H
Following the KEAP1 inactivation, the expression and the nuclear translocation of nuclear factor-erythroid 2 p45-related factor 2 (NRF2) are increased, which subsequently promotes the transcription of antioxidant proteins like superoxide dismutase 2 (SOD2) and heme oxygenase 1 (HO-1), and leads to the mitigation of synovial inflammation
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