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Here is the short version of what they do in the skin: So it is not just soothing for the sake of soothing

Pen Dosage Chart Dosage & Protocols Variations Standard Research Protocol Dose: 0.1 0.3 mg (= 412 clicks) Duration: 2 4 weeks Frequency: Once daily, prior to rest phase Cycle Interval: 2 weeks off before repeating Goal / Description: Baseline protocol used in sleep architecture and circadian rhythm research models

This is probably due to the formation of trimethylamine

Vitamin C is necessary for collagen synthesis[2], helping to maintain skin structure and slow signs of aging

No study has compared a 4-week KLOW cycle with a 6-, 8-, 12-, or 16-week cycle

"A review on the nutritive value and toxic aspects of Leucaena leucocephala" (PDF)