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These drugs activate key signaling pathways, such as PI3K/Akt and AMPK, which enhance mitochondrial biogenesis and promote neuronal survival

Metabolism 77:6572 Gaborit B, Ancel P, Abdullah AE, Maurice F, Abdesselam I, Calen A, Soghomonian A, Houssays M, Varlet I, Eisinger M, Lasbleiz A, Peiretti F, Bornet CE, Lefur Y, Pini L, Rapacchi S, Bernard M, Resseguier N, Darmon P, Kober F, Dutour A (2021) Effect of empagliflozin on ectopic fat stores and myocardial energetics in type 2 diabetes: the EMPACEF study

About 37% of individuals prescribed semaglutide for obesity achieved 10% or more body weight reduction as compared to 16.6% of those prescribed semaglutide for T2D, 14.5% of those prescribed liraglutide for obesity, and 9.3% of those receiving liraglutide for T2D

Step 3: Clean everything

Most patients lose 58% of body weight during this phase