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Morphologically, ferroptosis is marked by a decrease or disappearance of mitochondrial crests, rupture and contraction of the outer mitochondrial membrane, and shrinkage and darkening of the volume and color of the mitochondria, but the morphological changes in the nucleus are not obvious (28, 29)

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With orforglipron offering additional advantages such as the elimination of strict pre-dosing requirements, potential lower cost, and easier storage, it will be important to see whether these features lead to even greater adherence, says Priya Jaisinghani, a diabetes and obesity medicine specialist at NYU Langone