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In aquatic organisms, ibuprofen has been linked to oxidative stress, cytotoxicity, genotoxicity, and neurotoxic effects, including changes in behavior (Sibiya et al., 2023)

With increased pro-inflammatory cytokines and decreased anti-inflammatory cytokines in GD, IDO can be activated, resulting in greater tryptophan consumption and decreased 5-HT accessibility (41, 42)

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