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Notably, 10,182 cases (35.2%) were recorded as other indications or lacked documented indications

Figure 5 4 Discussion PCOS is a prevalent endocrine and metabolic disorder that impacts 8-13% of women in their reproductive years ( Curcumin has been extensively studied for its diverse biological activities, including potent anti-inflammatory, antioxidant, and anticancer properties ( Previous research has identified curcumin as a potent antioxidant, with its antioxidant properties attributed to the hydroxyl group and methylene group within its -diketone structure ( Curcumin mitigates oxidative stress by upregulating PPAR- expression, a nuclear receptor integral to the regulation of inflammation, glucose metabolism, and lipid balance ( Previous studies have shown that curcumin can reduce serum testosterone and luteinizing hormone levels while alleviating insulin resistance in PCOS rat models ( The study has several limitations that should be acknowledged

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Additionally, the development of innovative drug delivery methods, such as oral administration, is enhancing patient adherence, accelerating the drug's adoption

On the other hand, people with type 2 diabetes exhibit more marked abnormalities in the fasting state, and these defects persist in response to hyperglycemia

L-carnitine could also increase blood flow to the brain due to elevated nitrate levels, which covert to nitric oxide when oxygen availability is low