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This page presents investigational context in a structured format suitable for research-focused audiences

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Mutations in C9orf72, TDP-43, VAPB, VCP , and FUS are known to disturb these ER-mitochondria associations and signaling (Stoica et al., 2014

[237] but, based upon the clinical use of carbonic anhydrase inhibitors, carbonic anhydrase activation in other tissues may be associated with adverse effects, such as ocular activation exacerbating glaucoma

Advise patients on the symptoms of hypersensitivity reactions and instruct them to stop taking RYBELSUS and seek medical advice promptly if such symptoms occur [see Warnings and Precautions (5.7)]