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During development, CHAC2 exhibits a role complementary to CHAC1 by enhancing pluripotency and stem cell renewal, whereas CHAC1 promotes differentiation

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Unlike deficiency states, which produce well-characterised neurological and haematological symptoms, there is no clearly defined clinical syndrome associated with B12 excess from supplementation alone

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While allergic reactions are extremely rare, some people may experience brief redness or mild irritation

doi: 10.1016/j.neurobiolaging.2015.05.022 416 ZhanX.StamovaB.JinL.-W.DeCarliC.PhinneyB.SharpF