They created a prodrug, PARx, that combines their targeted imaging probe with a powerful chemotherapy drug and tested it in the mice
In response, pancreatic beta cells secrete insulin that promotes glucose absorption primarily to the liver and skeletal muscles, where it is converted to glycogen
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However, these side effects werent confirmed to be associated with the treatment and could have been a coincidence and not related to the use of semaglutide
Gastroenterology 158 , 745750 (2020)