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reported that participants in the CR combined with exercise group experienced significantly higher rates of hip fractures (10 per 10 000 person-years) compared to controls (6 per 10 000 person-years)

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Furthermore, when the postnatal NSCs were implanted into the striatum of mice treated with 3-NP, they not only maintained high intrinsic SOD2 levels themselves, but were also able to express specific trophic factors such as ciliary neurotrophic factor (CNTF) and vascular endothelial growth factor (VEGF) to activate SOD2 in the endangered host striatal neurons (Madhavan et al., 2005

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