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Efavirenz has a long and variable half-life of 40-55 hours at steady state.2 Therapeutic concentrations have been measured up to several weeks after drug intake cessation in some patients.3 Efavirenz is an inducer of hepatic cytochrome P450 (CYP450), a group of enzymes involved in the metabolism of a wide variety of drugs.4 Induction of CYP3A4 leads to reductions in plasma concentrations of coadministered drugs that are metabolized by CYP3A4, potentially diminishing their therapeutic effects.5-7 Moreover, efavirenz itself is primarily metabolized by CYP2B6 and racially distributed pharmacogenetic differences in CYP2B6 activity seem to contribute to the high interindividual variability in efavirenz exposure.8 Etravirine, a next generation NNRTI, is approved for use in combination with other ARVs in treatment-experienced patients.9 Unlike older NNRTIs, etravirine retained efficacy in the presence of some common NNRTI-associated resistance mutations

Lea ms: Tirzepatida como antiinflamatorio: el descubrimiento que est sorprendiendo a la ciencia En este grupo ms pequeo, las 15.264 mujeres que tomaban frmacos GLP-1 fueron emparejadas con otras de la misma edad, raza, etnia, ndice de masa corporal, densidad mamaria y estado de diabetes para limitar el sesgo y los posibles factores de confusin

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2013;16:A15

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