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it is an active antioxidant that helps cells to protect from oxidative stress by neutralizing the free radicals

It also is required to make glutathione

To test whether this Keap1-independent mechanism contributes to Nrf2 degradation in MuSCs, we first examined the protein levels of Ser9-phosphorylated GSK3 (i.e., the inactive form, abbreviated as pGSK3) and total GSK3 in FISCs from both male and female mice by Western blot 52

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The activated caspases then cleave gasdermin, form pores in the cell membrane, and lead to cell lysis and secretion of IL-1 [55, 56]

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