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The second step is catalyzed by GSH synthase, which adds glycine to -glutamylcysteine to form -glutamylcysteinylglycine or GSH

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Rectal administration of butyrate ameliorates pulmonary fibrosis in mice through induction of hepatocyte growth factor in the colon via the HDAC-PPAR pathway

These results have not been replicated in human clinical trials, so it is unclear whether these effects translate to human patients