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every other arm, including the slow 12 mg ladder, peaked and then settled into single digits. GIP activates an anti-nausea circuit, but that adaptation needs several weeks alongside a lower GLP-1 load
Although our disproportionality analysis did not identify headache as a statistically significant NAE signal, it represented the most frequently reported adverse event with 7,132 cases
That matches the standard titration period before increasing to 5mg
What remains unknown Despite encouraging data, genuine unknowns exist: Effects beyond 6-9 months of continuous use have not been formally studied in animals or humans
